Home | Site map | Newsletter | Contact us 

Hormone therapies for cancer

hormones breast prostate cancer tamoxifen femara exemestane arimidex zolafex

      Radiotherapy  |  Hormone therapy  | Biological therapiesLifestyle & cancer 

Google

Links: Breast cancer | Prostate cancer | Tamoxifen | Arimidex | Aromasin | Femara | Zoladex | Provera | Megace | Faslodex | Cyproterone | Toremefine | Stilboestrol | Exercise | Diet
Receive monthly lifestyle research updates
Email:  
This inspiring new book, based only on the facts - describing what you can do to help your chances of living longer & stronger
 .read more/order
An imbalance of micro nutrients, vitamins, omega-3, minerals increases the risk of cancer. Measuring your blood levels will empower you with optimal dietary choices
..read more

Many tumours (cancers) are stimulated by the body's own hormones (usually the female hormone oestrogen or the male hormone testosterone). Some of these cancers can be stimulated by female hormones taken deliberately such as HRT or hormone replacement therapy. Cancers with hormone receptors can also be promoted and stimulated to grow by ingested chemicals which have oestrogenic properties (see xenoestrogens and metaloestrogens)

Stopping the body's hormones reaching the nucleus of the cell cause the cancer cells to stop growing and in some cases shrivel up and die (self destruct - apoptosis). Most of the successful therapies in this category are for breast and prostate cancer but they have been used with limited success in uterine, kidney cancer and melanoma. 

Although hormones can be very successful treatments in some cancers especially breast and prostate they are associated with some short and long term side effects - fortunately there are useful self help lifestyle tips which can help:

Lifestyle and self help tips to help cope with the risks and side effects of hormones:

How do hormone therapies work?
The first way is to block the production of the bodies own hormones. One  straightforward way is to surgically remove the ovaries or testes. Some drug therapies chemically do the same thing by blocking the signal from the brain to the ovaries or testes - these include goserelin (Zoladex), leuproelin (Prostap) collectively called LHRH blockers. Other drugs in this category work by stopping the production of oestrogen from the adrenal glands. These only work in post menopausal women and the three most commonly used in the UK are anastrazole (Arimidex), exemestane (Aromasin) and letrozole (Femara).

The second way hormone therapies work is to fool the signal pathway between the  brain (pituitary) and the ovaries or testes by increasing the blood levels of another hormone produced in the ovaries so in turn the brain thinks they are producing too many hormones including oestrogen and as a consequence switches off the driving signal by itself - this results in reducing the blood level of oestrogen. Drugs which act in this way include Medroxyprogesterone acetate (Provera), Megestrol acetate (Megace), stilboestrol and cyproterone acetate.

The third way to stop the bodies hormones stimulating cancer cells to grow is to block  the cells ability to read the signal from the hormones in the blood stream. Cancer cells have receptors which when blocked they cannot be influenced by the bodies hormones, despite often normal levels in the blood stream. The most well known is called oestrogen receptor and can be blocked with tamoxifen and toremifene (selective oestrogen receptor modifiers -SERM's). These receptors can be measured by performing a special test on the tissue removed from the tumour (oestrogen receptor positive). In prostate cancer the receptors are called androgen receptors, Although they are not easy measured they can be blocked with drugs such as bicalutamide (casodex), Flutamide (Drogenil) and Buserelin (suprefact).

 

 

 

Links and further resources:

What is cancerAbout specific cancers; Breast | Prostate | Bowel.  Cancer treatments; Chemotherapy | Radiotherapy | Hormones | Biological agents | Complementary.  Lifestyle advice; Exercise | Diet | Smoking | Sunbathing | Alcohol.  Cope with symptomsTraveling | Insurance | Making a will | Support groups  | Tests for cancer | Clinical trials. ...site map
An excess or a deficiency of vitamins and trace mineral can lead to an increased risk of cancer, other illnesses and troublesome symptoms. A reliable way to ensure you have the correct amounts is to measure them. You will then be a to make able to make informed dietary decisions including and whether to take specific supplements in order to restore your nutritional balance. ...read more / order online
Cracked and sore lips are common during chemotherapy and afterwards. There is evidence that natural oil based creams are better than petroleum based creams. Nature-medical lip balm  contains only  natural waxes and essential oils selected for their anti-inflammatory and DNA stabilizing properties.. read more..order

Glossary  |   About us  |  Disclaimer  |  Contact us  |  How to advertise on this site