Genetic screening for cancer
The common cancers which can be detected through screening are Breast, Ovary and Colon cancer.
If you have developed breast, ovary or colon cancer and you have a strong family history you will be offered genetics testing in the UK on the NHS. Research studies are underway to discover the susceptible genes for other cancers such prostate. This will involve information and counseling for you and your family members. If you don't meet the criteria for screening there are some private clinics which also performing genetics screen on blood or cells taken from your mouth (buccal smear).
If you don't have a family history there is no evidence that a random screen is beneficial and may cause unnecessary distress.
Background Within each cell, in the human body, lies a structure called a nucleus, containing strips of material called DNA. To be precise 46 strips each containing millions of packages of information called genes. These genes are the codes and templates for all the functions of the entire human body. They have evolved over the centuries through countless generations to produce the human form we know today. Over this time our genes have picked up considerable amount of debris. Some of this debris includes strips of genes which actual cause cancer but are kept from mischief by other genes which lie next to them on the same strip of DNA. These good genes, called tumour suppresser genes, were themselves once randomly picked up through the evolutionary pathway but now serve the essential function of guarding the body from the bad cancer genes - we would get cancer without them. Essentially we were born with the tendency to get cancer - its part of us!
With thousands of potential cancers already programmed in our DNA it does not come as a surprise that 1 in 3 of us will get cancer at one stage in our lives. Perhaps instead of asking why me when we develop cancer we should be asking why not me when we don't?
With cancer already coded in our DNA guarded by other anti-cancer genes any re-arrangement of the DNA can lead to the start of the malignant process. The clue to why one person gets cancer and another does not, despite the same lifestyle probably lies in their genetic makeup – the cards they were dealt. Some people may have been born with a rather loose arrangement between their good and bad genes which could be separated by low carcinogen exposure in an apparently healthy lifestyle. Alternatively they could have an inherited defect in their suppressor genes. Examples of these include
The BCRA-1 or BCRA-2 gene mutation which increases the risk of breast & ovary cancer
The hereditary polyposis coli gene for bowel cancer.
Von Hippel Lindau syndrome for kidney cancer
Li'fraumany syndrome for sarcomas and other cancers
Other very rare syndromes include Browns syndrome, Morlyn's sundrome
On the other hand some people are fortunate to be born with their cancer genes locked in tightly by very stable suppresser genes resulting in a very robust DNA profile the has been no names given to these - people with these DNA profiles are simply called lucky! It will take an awful lot of chemicals in these individuals to damage the genes enough to cause cancer. These extreme cases are often quoted as excuses for hardened smokers. "He smoked 20 cigarettes a day, eats rubbish all his life and didn't get cancer". Most people, however are somewhere in between these two extremes so although we have an underlying risk of developing cancer which is outside our control, what we do to our bodies still has a great influences on our destiny.
If you are concerned about cancer and how it may interact with lifestyle this website (cancernet.co.uk) looks at the proven lifestyle risk factors including exercise, diet, smoking, sunbathing and alcohol. Alternatively, a book written by Professor Robert Thomas summarizes the evidence of how to avoid cancer, cope with its treatments and prevent its relapse. He also recently published the worlds largest prospective lifestyle study involving men with prostate cancer and has a special interest in lifestyle and cancer.
Further information: Your doctors and specialist nurses are in an ideal position to give information relevant to your situation. Cancernet.co.uk is a complete cancer information resource written by an experienced team of doctors, health professionals and patients. It will help you make informed decisions and guide you through the cancer journey including information about: Specific cancers: e.g. Breast | Prostate | Bowel. Specific treatments: Chemotherapy, Radiotherapy, Hormones, Biological agents. Tips to help with symptoms and side effects. Financial issues: Traveling and cancer | Travel insurance | Links to support groups | Books | Videos | Glossary | About us | Disclaimer | Tests for cancer | Clinical trials | What is cancer | How to avoid cancer Further information regarding Lifestyle and cancer: can be found within the sections: Exercise | Diet | Smoking | Sunbathing | Alcohol.