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     Osteoporosis, causes and lifestyle tips to maintain healthy bone density

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As we get older the bones tend to loose some density but many treatments for cancer can accelerate this process leading to a deficiency of  the amount of protein and calcium in the bone (the bone density). This may range from a mild reduction in the calcium density, measured on a bone density scan, to a moderate reduction called osteopenia through to a significant bone mineralisation loss with its associated risks of collapsed vertebrae and fractures (osteoporosis seen in the adjacent picture)

 

Factors which increase the risk of bone loss:

  • Immobility
  • Chemotherapy, especially if this induces the menopause in women.
  • The aromatase inhibitors (Arimidex, Letrozole or Exemestane).
  • Early menopause (removing or irradiating the ovaries, zoladex).
  • Reducing the male hormone, testosterone (surgery, radiotherapy, hormones - zoladex
  • Other medical conditions: thyroid dysorders, pituitary disorders
  • Long term use of warfarin, phenytoin

Lifestyle factors which help to maintain healthy bones:

Exercise: The bone is not a solid lump of calcium but a dynamic organ constantly re-moulding itself. As a result bone is strongly influenced by environmental and lifestyle factors and of these exercise is the most prominent. Put a man in space, for example and within 6 weeks he has osteopenia as there is no weight baring stimulus to the bone. In a less dramatic but similar way developing a sedentary lifestyle will result in bone thinning. Fortunately weight barring exercises will do the opposite. It sends signals to the cells in the bone to lay down more calcium and especially combined with an adequate diet  will prevent bone loss or increase it. Exercise, therefore is defense against bone loss and the exercise section describes ways to increase weight baring exercises in a fun controlled and regular way.

Dietary calcium is also important and it is not just found in dairy products such as milk, yogurt and cheese but in a wide range of less fatty foods such as sardines, broccoli, almonds and salmon.

Vitamin D serves several important functions in relation to calcium metabolism and is vital for the development of healthy bones. It helps to increase calcium absorption from the gastrointestinal system and kidney and thereby make it available to body tissues and the blood. It also functions to aide with the deposition of calcium to bone. The body’s main source of vitamin D arises from the manufacture of this vitamin in the skin on exposure to sunlight. Research has found many people are deficient in vitamin D due to more time being spent indoors. Only 10 – 15 minutes of exposure to outdoor sun is necessary for the production of vitamin D (see sense in the sun). Dietary sources of vitamin D are limited but sources arise often from foods fortified (boosted) with vitamin D such as milk, soya drinks and cereals. It is also found naturally in liver, fish (tuna, salmon, sardines, herring and mackerel) and egg yolk.

Plant based protein: A number of studies have demonstrated the importance of plant based proteins to help maintain bone density. In fact, individuals who consume their proteins from plant rather than animal sources actually have better bone density. These include lentils, soya, beans, pulses particularly quinoa.

Other lifestyle factors. The National osteoporosis risk assessment study identified several lifestyle factors that correlated with an increased risk of bone loss. These included being underweight (BMI < 18.5kg/m2), smoking (see quit smoking tips), drinking excess caffeine (>4 cups of coffee/day)

 


How to measure bone density

A DEXA scan measures bone density. It is a quick and painless test. DEXA stands for dual energy x-rays absorptiometry. There are two different types of DEXA scanning devices, central and peripheral. Central DEXA devices are large machines that can measure bone density in the centre of your skeleton, such as your hip and spine. Peripheral DEXA devices are smaller, portable machines that are used to measure bone density on the periphery of your skeleton, such as your wrist, heel or finger.

During a DEXA scan, you will be asked to lie on your back on a couch and to keep still while the scan is being taken. The scan usually takes between 10 and 20 minutes, depending on which part of your body is being examined, and whether a central or peripheral scanner is being used. There are no injections.

In order to check for osteoporosis, the doctor commonly scans the lower back bones (vertebrae) and hips. The forearm may also be scanned, because it has a different level of calcium content from other body parts.

No preparation for the test is required and, depending on which part of your body is being scanned, you may be able to remain fully dressed, in clothes without metal fastenings. It is a painless procedure and you can go straight home afterwards.

Most scans produce a T score and a Z score referring to the bone density in a number of areas of the body. Usually this includes the spine and hips but can often include the wrist and ankle. A T score of zero is normal. Less than zero means the bone density is impaired and your bone density may need some lifestyle or medical attention. The table below gives an example of management recommendations for varying T-scores. The Z score is basically a T score but adjusted to the age at the time of the scan

 

The management and rescanning interval is determined by the T-score:

T score > -1

T score  –1 to –2.5

T score less than –2.5

Dietary screen

Lifestyle advice

Lifestyle advice

Lifestyle advice

 

Calcium and vitamin D 

Bisphosphonate with calcium & vit D for 5 yrs.

Rescan at 18 months if taking an AI, 3 years on Tamoxifen

Rescan at 1 year

Rescan at 3-5 years

  * Z score (age adjusted) if < -2 refer patient to endocrine physician to investigate for endocrine abnormalities.

Other issues with bisphosphonates

Bisphosphonate prescribing; eg Risedronate 35mg or Aledronate 70mg PO once weekly. Always prescribe a calcium/vitamin D supplement such as Adacal-D

Weekly bisphosphonate dosing is effective, better tolerated than daily (avoids daily insult to oesophagus) with better compliance.

Dosing instructions are critical and should be reinforced at follow-up visit: take first thing in the morning, follow by drink of water, sit upright for 30 minutes, do not take lying down and do not eat or drink for 30 minutes after taking the tablet.

DEXA response to bisphosphonates is virtually universal (failure of response is a sign of non-compliance), so no need to rescan until end of five year course (more valuable to spend time ensuring compliance at each follow up visit).

Bisphosphonates are absolutely contraindicated in pregnancy so make sure younger patients are aware of this and taking appropriate precautions, even if apparently menopausal. A 6 month washout period is needed after risedronate if attempting to conceive (which is the same as the recommended tamoxifen washout period).

Patients who cannot tolerate oral bisphosphonates and have T scores less than -2.5 should be given monthly pamidronate infusions for five years.  Other intravenous preparations as they become licensed may become preferable.

Patients who have moderate to severe renal failure should only take Bonefos only under strict supervision. Care should be taken with Bonefos if it is taken with non-steroidal anti-inflammatory drugs.

 

Helpful resources and links

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Lifestyle and cancer - the facts. This 2011, edition with a foreword from Paula Radcliffe has been extensively re-written with evidence from the latest research from around the world which demonstrates how diet, exercise and lifestyle changes can; help avoid cancer (read chapter 9 free), cope with treatments side effects; slow the rate of progression of cancer and help prevent  relapse.  This comprehensive essential lifestyle guidebook can be ordered online (£8.95), or downloaded via kindle
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Keep-healthy.com Practical evidence based advice on healthy living including ways to naturally reduce cholesterol, reduce blood pressure, keep healthy eyesight, hearing, maintain a healthy weight and level of fitness. Includes advice on supplements and other useful products...link
Support groups and self help organisations throughout the UK and internationally. Links to Asian support organisations; Read patient stories, poems and links to the Cancer active website addressing a wide range of complementary issues related to cancer and their a quarterly magazine (ICON)..  submit a link to your group

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