This page summarises a few of the ongoing UK lymphoma trials. These many not be available in your area.
 UKLG LYO7 - Minimal initial therapy (MIT) for "early" Hodgkin's disease
A multicentr randomised trial of short neoadjuvant chemotherapy (VAPEC-B) plus involved field radiotherapy (MIT) versus mantle radiotherapy.
VAPEC-B see chemotherapy section
Involved field - see radiotherapy section
Dr MV Williams
Addenbrooke’s Hospital, Cambridge. 01223 217020
Dr JA Radford
The Christie Hospital, Manchester. 0161 446 3000 ex 3753
Dr G Vaughan Hudson BNLI 0171 631 4787 or 0171 380 9428
 BNLI-1 - Study of poor risk intermediate or high grade NHL
Objectives Of Study
To assess in a prospective randomised trial the value of early intensification with autologous bone marrow or stem cell support in patients with poor prognosis intermediate/high grade Non-Hodgkin's Lymphomas.
Patient randomisation, 3 cycles of CHOP followed by response assessment. If responding patient proceeds to next stage which is either further CHOP to CR + 2 (min 6) cycles or BEAM + ABMT as decided at randomisation.
Age 16 - 65 years
No medical conditions prohibiting intensive therapy.
No systemic treatment for cancer in previous 5 years.
Histology follicular large cell lymphomas
diffuse mixed cell lymphomas
diffuse large cell lymphomas
diffuse immunoblastic lymphomas
All histology to be reviewed by panel (to be established). This can be done after randomisation and where necessary patients will subsequently be excluded from the study.
Poor prognostic features defined as the presence of 2 or 3 of :
i stage III/IV
ii LDH > normal
iii Performance status 2-4 (ECOG - WHO)
Full clinical staging to include CT scanning of abdomen and bone marrow trephine biopsy.
Randomisation (within 2 weeks of starting chemotherapy):
Dr G Vaughan Hudson. Tel 071 631 4787 or 071 380 9428 (direct lines)
Fax 071 380 9427
Beam + ABMT
High dose therapy and ABMT to be carried out in weeks 9 or 10. Although this is a very narrow window, the early randomisation will allow "booking of harvest dates" two months in advance. Full details in protocol folder.
 BNLI - 2 Study of chemotherapy in elderly patientss (PAdriaCEBO v PMitCEBO)
Aims Of Current Trial
To be carried out by telephone to the BNLI Secretariat on 071 631 4787 (direct line)
or 071 636 8333 Ext 3233/3234 before starting any therapy
Details of Protocol - see chemotherapy protocols
 LYO3 study
A protocol for a randomised trial of observation versus chlorambucil after anti-heliocbacter therapy in low grade gastric lyphoma.
All patients have anti-heliobacter treatment (see above)
[A] CR - observation or Chlb
[B] PR - observation or Chlb
Randomisation number 0171 631 4787.
 LYO4 study
A study to investigate the benefit of adjuvant chemotherapy following resection of localised gastrintestinal intermediate and immunoblastic high grade NHL and to assess the effect of the depth of penetration of the tumour on survival.
All patients are required to have complete surgical resection
[A] T1-2, N0,M0 either CHOP x3 or observation only
[B] T3-4, n0-2, M0 either CHOP x3 or CHOP x6
CLINICAL Co-ORDINATOR - Dr David Cunningham RMH Sutton.
Randomisation number 0171 631 4787.
 LY09 study
A randomised trial of chemotherapytherapy in advanced Hodgkin’s disease
Eligibility: Stage IB, IIB, III & IV. Stage IA with bulky disease ( Def: Mediastinal mass > 1/3 rd the interthoracic ratio at d5/6. or a nodal mass > 10 cm). Stage IIA with 3 or more sites of disease or bulky disease.
[B] ChlVPP/PABLOE or hybrid BEACOP.
Further general information Your doctors and specialist nurses are in an ideal position to give you relevant information on your disease and treatment as they know your individual circumstances. Cancerbackup has a help line (0808 800 1234) and a prize winning video available in English, Italian, Urdu, Bengali, Gujarati & Hindi explaining Radiotherapy & Chemotherapy. Cancernet.co.uk has over 500 pages describing cancer, its management, practical tips and tool which patients, their carers and their doctors have found helpful during the cancer journey.