|
Histological classification |
There are different types of lymphoma and they all behave slightly differently. There are also different ways to class the disease. In Hodgkin's disease there are two main ways - RYE classification and REAL classification. In Non-Hodgkins Lymphoma there are several including. Working formulation, REAL and KEIL classification.
HODGKINS LYMPHOMA
RYE (Luke's et el Can Res. 1966. 26; 1311). Also see REAL classification (within NHL section)
| Lymphocyte predominance | Including nodular and diffuse variants of lymphocytic and/or histiocytic proliferation |
| Mixed cellularity | |
| Nodular sclerosis | Including variant where sclerosis is sparse: cellular phase |
| Lymphocyte depleted | Including diffuse fibrosis and reticular categories |
NON HODGKINS LYMPHOMA
Working formulation classification of non-Hodgkin s lymphomas
Rosenberg S.A et al. Cancer 49: 2112-35, 1982 (Rappaport terminology)A Malignant Lymphocytic small Diffuse well differentiated
Lymphocytic consistent with lymphocytic
chronic lymphocytic leukaemia
plasmacytoid
B Malignant Lymphoma, follicular Nodular poorly differentiate/ lymphocytic
Predominantly small cleaved
cell diffuse areas sclerosis
C Malignant Lymphoma follicular Nodular mixed lymphocytic / Histiocytic
Mixed, small cleaved and
large cell diffuse areas sclerosis
D Malignant Lymphoma, Nodular histiocytic
follicular
Predominantly large cell
diffuse area / sclerosis
E Malignant Lymphoma, diffuse Diffuse poorly
small cleaved cell differentiated lymphocytic
F Malignant lymphoma, diffuse Diffuse mixed
Mixed, small and large cell lymphocytic-histiocytic
sclerosis
epitheloid cell component
G Malignant Lymphoma, diffuse Diffuse histiocytic
Large cell
cleaved cell / sclerosis
H Malignant Lymphoma Diffuse histiocytic
large cell, immunoblastic
plasmacytoid / clear cell
polymorphous
epitheloid cell component
I Malignant Lymphoma Diffuse lymphoblastic
lymphoblastic
convoluted cell
J Malignant Lymphoma Diffuse undifferentiated
small non-cleaved cell
Burkitt's
follicular areas
REAL CLASSIFICATION (BLOOD, 1994. Vol.84, No. 5, pp.1361-1392 & Pileri et al Current opinion in oncology 1995,7:401)).
B-cell
B-cell chronic lymphocytic leukaemia
Lymphocytic small B-cell lymphoma
Plasmacytoid and myeloma
Hairy cell leukaemia
Marginal zone B-cell lymphoma
Follicle center lymphoma, follicular (grades 1&2)
T-Cell
Large granual lymphocytic leukaemia
Adult T-cell lymphoma or leukaemia (Smouldering)
Mycosis fungoides, Sezary’s syndrone
B-cell
B-cell pro-lymphocytic leukaemia
Mantle cell lymphoma*
Follicle centre lymphoma, follicular (grade3)
T-cell
T-cell CLL, prolymphocytic leukaemia
Adult T-cell lymphoma, leukaemia (Chronic)
Angiocentric ymphoma*
Angio-immunoblastic lymphoma*
B-cell
Diffuse large B-cell lymphoma
T-cell
Peripheral T-cell lymphoma, unspecified
Intestinal T-cell lymphoma
Anaplastic large-cell lymphoma
Adult T-cell lymphoma or leukaemia (acute and lymphomatous)
B-cell
Precursor B-cell lymphoblastic lymphoma, leukaemia
Burkitt’s lymphoma
High grade B-cell lymphoma, Burkitt’s - like
T-cell
Precursor T lymphoblastic lymphoma, leukaemia
Lymphocyte predominance
Others * These types should be referred to Dr Marcus
KIEL CLASSIFICATION
| B CELL LYMPHOMA | T CELL LYMPHOMA |
| Low grade malignancy | Low grade malignancy |
| Lymphocytic Lymphoplasmacytic Plasmacytic Centroblastic/centrocytic follicular diffuse Centrocytic |
Lymphocytic Small cerebriform cell mycosis fungoides sezary’s syndrome Lymphoepithelioid (Lennert’s syndrome) Angioimmunoblastic T-zone Pleomorphic small cell |
| High grade maligancy | High grade maligancy |